Storm Preparations

Carotid Ultrasound Post-Intervention for Detection of Disease (CUPIDD)

Considering that atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in the Western world, there is a vital need to develop novel imaging modalities able to identify subclinical disease. Coronary angiography is the current standard of care to define atherosclerotic disease, yet its invasive nature is a significant disadvantage. Conversely, non-invasive B-mode ultrasonic imaging of the carotid arteries is able to detect early increases in the carotid intimal-medial thickeness (CIMT), which may act as a systemic barometer of atherosclerotic disease. Additionally, 3-dimensional ultrasonic imaging has the ability to quantify carotid plaque volume, providing another potential indicator of subclinical systemic atherosclerotic disease. In this project, our main objective was to correlate CIMT and with the presence of atherosclerosis determined by angiography in a large outpatient population. Secondarily, we quantified the amount of carotid plaque volume (PV) and correlated this result with angiographic atherosclerosis. Our results indicate that complete carotid ultrasound (B-mode and 3D) may serve as a simple, inexpensive, and low-risk test to rule out significant atherosclerotic cardiovascular disease.

Funding: SEAMO Innovation Grant


CINQ Publications:

  1. Johri AM, Behl P, Hétu M-F, Haqqi M, Ewart P, Day AG, Parfrey B, Matangi MF (2016) Carotid Ultrasound Plaque Height is a Sensitive Imaging Biomarker for the Assessment of Significant Coronary Artery Disease. Echocardiography 33(2):281-9.
  2. Johri, AM, Spence, JD. (2013) Barometer in the Storm – Carotid Artery Plaque Quantified by Three-Dimensional Ultrasound. J Am Soc Echocardiogr 26(8): 20A.
  3. Johri AM, Chitty D, Malik P, Matangi M, Malik P, Mousavi P, Day A, Simpson C. (2013). Can Carotid Bulb Plaque Assessment Rule out Significant Coronary Artery Disease? A Comparison of Plaque Quantification by Two- and Three-dimensional Ultrasound. J Am Soc Echocardiogr, 26(1):86-95.