Novel Ultrasound-Guided Microcarriers for Atherosclerosis Targeted Therapy (NUGATT)

High-tech imaging is advancing new frontiers in clinical research at Kingston Health Sciences Centre. Dr. Amer Johri, Director of the Cardiac Imaging Network Queen’s (CINQ), is working with Dr. David Rival, (PhD, PEng) Associate Professor, Mechanical and Materials Engineering, to develop new capabilities in carotid ultrasound for better analysis and treatment of atherosclerotic plaques in the novel field of theranostics.  Dr. Rival is an expert in experimental fluid dynamics, and together with Dr. Johri will develop methods of tracking microbubble technology.

Ultrasound-guided microcarriers have emerged to treat conditions such as cancer, by delivering therapeutic agents such as genetic vectors, proteins and chemotherapy. The NUGATT program aims at bringing this technology to heart disease through a bilateral collaboration between Queen’s University (Dr. Johri) and Sun Yat-sen University (Dr. Zhou).

 

Publications:

  1. Huang W, Chen Y, Chen L, Zhong J, Johri A, Zhou J. (2019) Multi-modality Imaging-Guided Local Injection of Eccentric Magnetic Microcapsules with Electromagnetically Controlled Drug Release. Cancer Reports. (in press)
  2. Tang J, Mi J, Huang W, Zhong H, Li Y, Zhou J, Johri AM. (2018) Controlled drug release from ultrasound-visualized elastic eccentric microcapsules using different resonant modes. Journal of Materials Chemistry B. 6(13).

 

Funded by:

Ontario-China Research and Innovation Fund (OCRIF)

Ontario Centres of Excellence (OCE)

Ministry of Science and Technology of the People’s Republic of China (MOST)